Conformation-specific anti-Factor IX antibodies



Crystal structure of the complex of the 10C12 Fab and Factor IX-(1-47). A ribbon diagram depicts the Fab fragment of the antibody 10C12. Light chain is shown in light blue, and heavy chain is shown in dark blue. Factor IX-(1-47) is also shown as a ribbon diagram, colored blue to yellow from the N terminus to the C terminus. Six calcium ions are shown from Ca-1 to Ca-7. Ca-6 is not present in this structure. Residues 1, 5, 6, 9, 11, and 45 in Factor IX-(1-47) are labeled. The side chains of residues 5, 6, 9, and 11 are included.

Additional Resources
For additional information, see: Hemophilia